For an economically competitive biological process, achieving high carbon yield of a target chemical is crucial. In biochemical production, pyruvate and acetyl-CoA are primary building blocks. When ...

Acetate can be used by tumour cells as an important bioenergetic fuel or as a nutritional source to support lipid biosynthesis. Acetate can be a precursor for acetylation of histones and other ...

Immune cells use two different routes to produce acetyl-CoA, an essential metabolite required to fight infection and cancer, reports a study led by Van Andel Institute scientists. The findings, ...

Insufficient acetyl-CoA derails the immune system's ability to protect the body. Until now, however, it was unclear exactly how immune cells maintained their acetyl-CoA reserves. In their new study, ...

Natural biological systems cannot efficiently convert waste CO₂ or its derivatives into useful building-block chemicals at a scale that can keep pace with rising atmospheric carbon. Engineer a fully ...