Trypanosoma brucei, the causative agent of sleeping sickness in humans, diverged from the highest eukaryotic lineage several hundred million years ago. Understanding epigenetic regulation in T. brucei ...

Single specimens of the vermicular pathogens causing sleeping sickness swim inside the gut of the tsetse fly between blood cells which the fly has ingested from an infected mammal. This is where they ...

Trypanosome parasites cause sleeping sickness in Africa. If left untreated, the infection causes coma and eventually death. A study published on July 21st in PLOS Pathogens takes a close look at what ...

Using cryo-electron microscopy, researchers have analyzed the structure of trypanosomes parasites in details and revealed one of their potential weak points, which has remained undetected until now.

Trypanosome parasites transmitted by tsetse flies cause devastating diseases in humans and livestock. Different subspecies infect different hosts: Trypanosoma brucei brucei infects cattle but is ...

African trypanosomes establish deadly, chronic infections of trypanosomiasis in the bloodstream by using repetitive 70-bp regions in the genome to regularly change out the active coat protein gene.

The immune system responds to an infection by producing antibodies that recognize and bind to the cell surface of the pathogen, thus marking it as an intruder and triggering an immune response. For ...

University of York researchers have identified a protein called ESB2 that functions as a “molecular shredder” inside the parasite responsible for sleeping sickness, selectively destroying RNA messages ...

The African trypanosome Trypanosoma brucei is a blood parasite capable of infecting many mammals. Humans are provided with natural immunity against infection through the activity of the protein ...

African trypanosomes establish deadly, chronic infections of trypanosomiasis in the bloodstream by using repetitive 70-bp regions in the genome to regularly change out the active coat protein gene.