The tumor suppressor protein p53 plays a critical role in preventing cancer by regulating cell cycle, apoptosis, and genomic stability. However, mutations in the P53 gene are found in over 50% of ...

Researchers showed that small engineered proteins can restore the function of mutated p53 by stabilizing its structure. The ...

Each year, 20 million people are diagnosed with cancer. Various organs can be affected, and cancer types sometimes differ ...

In the 1970s, scientists knew that some viruses and chemicals caused cancer, but they didn’t know how. Arnold Levine, a biologist currently at the Institute for Advanced Study researched DNA viruses ...

An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, known as the "guardian of the genome" for its ability to repair DNA damage or destroy cancerous cells.

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney Kimmel ...

The tumor suppressor protein p53 is mutated in more than half of all human cancers. Several drugs that potentially can restore mutant p53 to its normal cancer-killing function are in clinical ...

Cancer biologist Scott Lowe says the p53 discovery came as a complete surprise and suggests a new way to think about treating cancer. More than half of all cancers have mutations in a gene called p53.

Researchers have discovered that aneuploidy drives gain-of-function phenotypes in cells expressing mutant p53. Their report has implications for developing therapies targeting mutant p53. The tumor ...