Nature

The ‘N-factors’ in pancreatic cancer: functional relevance of NF-κB, NFAT and Nrf2 in pancreatic cancer

Thus, limitations in curative and, especially, palliative treatment options of PDACs demonstrate a need for new and gemcitabine-independent strategies. 10, 11 Over the last couple of years, the ...
Nature

Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-κB transcription factors

Tyrosine kinases couple the T cell receptor (TCR) to discrete signaling cascades, each of which is capable of inducing a distinct functional outcome. Precisely how TCR signals are channeled toward ...
Drexel University

Novel Calcium Dependent Mechanisms of NF-kappaB Activation Regulate Lymphocyte Tolerance & Immunity

Bruce D. Freedman, VMD, PhD, Associate Professor, School of Veterinary Medicine, University of Pennsylvania Uri Hershberg, PhD, Associate Professor, School of Biomedical Engineering, Science and ...