Researchers discovered that proteins SMG5 and SMG6 combine to form an active endonuclease that cuts faulty mRNA during nonsense-mediated decay. Individually weak or inactive, the proteins together ...

Researchers from the University of Cologne and the Max Planck Institute of Biochemistry show that the targeted interaction of two proteins ensures that a key control mechanism in the formation of prot ...

How does the cell convert DNA into working proteins? The process of translation can be seen as the decoding of instructions for making proteins, involving mRNA in transcription as well as tRNA. But ...

In today’s rapidly evolving scientific landscape, eliminating barriers to progress is more critical than ever. Precision medicine and targeted therapies hold great promise but are dependent on the ...

Drugs made of mRNA have the potential to transform medicine—if only they could get into cells in one piece. Now, University ...

We’re celebrating 180 years of Scientific American. Explore our legacy of discovery and look ahead to the future. In 1957, just four years after Francis Crick and other scientists solved the riddle of ...