A UCLA study found that macrophages rely on interferon gamma signaling from past infections to preserve innate defenses.

Cells have sophisticated methods of sensing stimuli and communicating with nearby cells in response to these stimuli. For example, macrophages can sense environmental stimuli—tissue damage, foreign ...

Researchers from the University of California, Los Angeles, have discovered that immune cells known as macrophages remain ...

NEW UNDERSTANDING: Kelvin Cooper predicts an upswing in interest because of new developments like comprehending the cytokine signaling pathway. Biochemical message-routing molecules are being ...

Schematic diagram of the IL-6/JAK/STAT3 signaling pathway activation in mouse liver macrophages. IRs, inhibitory receptors (IRs); ICIs, immune checkpoint inhibitors; IL-6, interleukin-6; ALT, alanine ...

The study identified 32 differentially expressed proteins in IPF, highlighting cytokine dysregulation as a key molecular feature of the disease. Five hub proteins—FGF2, HGF, HBEGF, ERBB3, and ...

Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, ...

A tissue section from a mouse model of lung metastasis showing cancer cells (green) that have attracted and activated fibroblasts (red) to support the growth of a metastatic tumor. Image: Massagué Lab ...