Researchers at the Icahn School of Medicine at Mount Sinai have developed an innovative approach—demonstrated in mouse models and isolated human brain tissue—to safely and effectively deliver ...

Our brain is an extremely complex and delicate organ. Our body fiercely protects it by holding onto things that help it and keeping harmful things out, such as bugs that can cause infection and toxins ...

The brain is among the most “immune-privileged” of organs primarily through the highly selective permeability of the blood-brain-barrier (BBB), its minimal lymphatic drainage, the presence of ...

Scientists from the University of Liverpool and their global collaborators have highlighted the most effective treatments for neurological diseases by overcoming one of medicine's most difficult ...

A new experimental treatment may have found a way to outsmart glioblastoma’s toughest defense: the blood-brain barrier.

The blood–brain barrier (BBB) is a highly selective endothelial interface that safeguards the central nervous system but simultaneously impedes the delivery of most pharmacological agents.

Peter Searson is leading a Johns Hopkins University team that is unravelling how Alzheimer's and other diseases disrupt the blood-brain barrier, the complex interface that allows or blocks the passage ...

“If we want to address BBB dysfunction, we have to have a good human BBB model,” said Ziyuan Guo, a neurobiologist and stem cell scientist at Cincinnati Children's Hospital Medical Center. “The whole ...

Neurodegenerative disorders such as Alzheimer's disease affect more than 270 million people worldwide. AD is the leading cause of dementia, resulting in memory loss due to atrophy of neurons in the ...

Repeated head knocks cause long-term damage to the delicate blood-brain barrier, potentially driving chronic traumatic encephalopathy (CTE), a neurodegenerative condition that affects some former ...

Researchers developed an innovative approach -- demonstrated in mouse models and isolated human brain tissue -- to safely and effectively deliver therapeutics into the brain, providing new ...